Patents

US 8,383,594

Peptides modified with triterpenoids and small organic molecules: Synthesis and use in cosmeceuticals

Filling date: August 07, 2007

Issue date: February 26, 2013

Inventors: Muhammed Majeed, Renukeshwar H Chandramouli, Kalyanam Nagabhushanam, Rattan Sood, Subbalakshmi Prakash, Sushmita Anand

Assignee: Sami Labs Limited

Abstract: The present invention relates to the synthesis of Triterpenoid peptides and mechanism of action for anti-aging and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti-aging activity by regenerating the dermal matrix. In detail, the present invention is relates to the synthesis of terpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of aging such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The triterpenoid peptides of the present invention with its novel dual action mode can be used for skin aging and collagen insufficiency. Its titerpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptide which boost the collagen and other matrix protein, triterpenoid peptides provide a complete protection against premature aging and functions as a best anti-aging ingredient.

US 8,987,212

Oleanoyl peptide composition and method of treating skin aging

Filling date: December 28, 2010

Issue date: March 24, 2015

Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Renukeshwar H Chandramouli, Rattan Sood, Subbalakshmi Prakash, Sushmita Anand Tathapudi

Assignee: Sami Labs Limited

Abstract: The present invention relates to a composition containing peptides of Serine-Lysine-Threonine-Threonine-Lysine linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of aging due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature aging.

US 10,071,043

Oleanoyl peptide composition and skin hydration

Filling date: December 30, 2015 (Filing date of parent application Aug. 7, 2007)

Issue date: August 30, 2018

Inventors: Muhammed Majeed, Kalyanam Nagabhushanam

Assignee: Sami Labs Limited

Abstract: Disclosed is a method of effecting skin hydration and enhancing skin barrier function, said method comprising the step of bringing into contact a pentapeptide conjugate of oleanolic acid with skin cells so that the effect of increased cellular communication at the molecular level to bring about gene and protein expression in the cells of the skin that enable hydration and skin barrier functions are realized.

AU2011265587

Oleanoyl peptide composition and a method of treating skin aging

Filling date: December 28, 2010

Issue date: April 20, 2017

Inventors: Muhammed Majeed, Renukeshwar H Chandramouli, Kalyanam Nagabhushanam, Rattan Sood, Subbalakshmi Prakash, Sushmita Anand

Assignee: Sami Labs Limited

Abstract: The present invention relates to a composition containing peptides of Serine-Lysine-Threonine-Threonine-Lysine linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of aging due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature aging.

JP6176893

Oleanoyl peptide composition and a method of treating skin aging

Filling date: December 28, 2011

Issue date: July 21, 2017

Inventors: Muhammed Majeed, Renukeshwar H Chandramouli, Kalyanam Nagabhushanam, Rattan Sood, Subbalakshmi Prakash, Sushmita Anand

Assignee: Sami Labs Limited

Abstract: The present invention relates to a composition containing peptides of Serine-Lysine-Threonine-Threonine-Lysine linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of aging due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature aging.